We may not be very far away
from a time when dentists offer to help people with
damaged or missing teeth grow new ones, according to new
research presented on Wednesday.
A series of presentations at
a dental meeting demonstrate that techniques using stem
cells and gene therapy to regenerate teeth are producing
promising results, suggesting this technique may not be
far off.
"I think it's looking like
quite an exciting technology for the near future," said
Dr. Tony Smith, editor of the Journal of Dental Research,
who was not involved in any of the newest studies.
Smith explained that the
presentations describe techniques that enable dentists to
coax existing teeth into repairing and regenerating
themselves, and techniques where dentists can "start from
scratch."
Clearly, techniques that
involve adding new tissue to already-existing teeth are
"probably a bit closer on the horizon," perhaps within a
"handful of years," Smith predicted. Techniques that grow
teeth from scratch will likely take at least another 10
years to perfect, he added.
In some instances,
researchers are trying to reprogram cells in the mouth to
behave like tooth-growing cells, convincing them they have
to produce new teeth, Smith explained.
Other techniques being
explored involve using stem cells, which have the
potential to become any type of cell or tissue. In one
study being presented at the meeting, researchers
successfully extracted stem cells from the pulp of adult
teeth, Smith said. The next step is to examine whether
it's possible to use these teeth to regenerate new dental
tissue, he said.
Other research being
unveiled describes tests of different approaches to select
stem cells from pulp, and all shows "different degrees of
success," Smith said.
These techniques may one day
help people whose teeth have decayed from very bad
cavities, who have lost teeth in an accident, or whose
teeth have worn down from acid or hard brushing, among
other conditions, he predicted.